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Use of the Hydantoin Isostere to Produce Inhibitors Showing Selectivity Toward the Vesicular Glutamate Transporter versus the Obligate Exchange Transporter System x(c)(−)
Evidence was acquired prior to suggest that the vesicular glutamate transporter (VGLUT) but not other glutamate transporters were inhibited by structures containing a weakly basic α-amino group. To test this hypothesis, a series of analogs using a hydantoin (pKa ~ 9.1) isostere were synthesized and...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3159025/ https://ncbi.nlm.nih.gov/pubmed/21669531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.018 |
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