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Use of the Hydantoin Isostere to Produce Inhibitors Showing Selectivity Toward the Vesicular Glutamate Transporter versus the Obligate Exchange Transporter System x(c)(−)

Evidence was acquired prior to suggest that the vesicular glutamate transporter (VGLUT) but not other glutamate transporters were inhibited by structures containing a weakly basic α-amino group. To test this hypothesis, a series of analogs using a hydantoin (pKa ~ 9.1) isostere were synthesized and...

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Bibliografiske detaljer
Main Authors: Ahmed, S. Kaleem, Etoga, Jean-Louis G., Patel, Sarjubhai A., Bridges, Richard J., Thompson, Charles M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159025/
https://ncbi.nlm.nih.gov/pubmed/21669531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.05.018
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