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Preclinical studies on targeted delivery of multiple IFNα2b to HLA-DR in diverse hematologic cancers

The short circulating half-life and side effects of IFNα affect its dosing schedule and efficacy. Fusion of IFNα to a tumor-targeting mAb (mAb-IFNα) can enhance potency because of increased tumor localization and improved pharmacokinetics. We used the Dock-and-Lock method to generate C2-2b-2b, a mAb...

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Detalhes bibliográficos
Main Authors: Rossi, Edmund A., Rossi, Diane L., Cardillo, Thomas M., Stein, Rhona, Goldenberg, David M., Chang, Chien-Hsing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158718/
https://ncbi.nlm.nih.gov/pubmed/21680794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-343145
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