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Preclinical studies on targeted delivery of multiple IFNα2b to HLA-DR in diverse hematologic cancers
The short circulating half-life and side effects of IFNα affect its dosing schedule and efficacy. Fusion of IFNα to a tumor-targeting mAb (mAb-IFNα) can enhance potency because of increased tumor localization and improved pharmacokinetics. We used the Dock-and-Lock method to generate C2-2b-2b, a mAb...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society of Hematology
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158718/ https://ncbi.nlm.nih.gov/pubmed/21680794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-343145 |
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