The Metabotropic Glutamate 2/3 Receptor Agonist LY379268 Blocked Nicotine-Induced Increases in Nucleus Accumbens Shell Dopamine only in the Presence of a Nicotine-Associated Context in Rats

The metabotropic glutamate 2/3 (mGlu2/3) receptor agonist LY379268 ([−]-2-oxa-4-aminobicyclo [3.1.0] hexane-4,6-dicarboxylate) attenuates both nicotine self-administration and cue-induced nicotine seeking in rats. In this study, the effects of LY379268 (1 mg/kg) or saline pretreatment on nicotine-in...

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Main Authors: D'Souza, Manoranjan S, Liechti, Matthias E, Ramirez-Niño, Ana M, Kuczenski, Ronald, Markou, Athina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158309/
https://ncbi.nlm.nih.gov/pubmed/21654734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.103
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