Tumor Suppressor Role for the SPOP Ubiquitin Ligase in Signal-Dependent Proteolysis of the Oncogenic Coactivator SRC-3/AIB1

Steroid receptor coactivator-3 (SRC-3/AIB1) is an oncogene that is amplified and overexpressed in many human cancers. However, the molecular mechanisms that regulate ‘activated SRC-3 oncoprotein’ turnover during tumorigenesis remain to be elucidated. Here we report thatspeckle-type POZ protein (SPOP...

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Main Authors: Li, Chao, Ao, Junping, Fu, Junjiang, Lee, Dung-Fang, Xu, Jianming, Lonard, David, O’Malley, Bert W.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158261/
https://ncbi.nlm.nih.gov/pubmed/21577200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.151
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