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Nonrandom attrition of the naive CD8(+) T-cell pool with aging governed by T-cell receptor:pMHC interactions
Immunity against new infections declines in the last quartile of life, as do numbers of naive T cells. Peripheral maintenance of naive T cells over the lifespan is necessary because their production drastically declines by puberty, a result of thymic involution. We report that this maintenance is no...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158207/ https://ncbi.nlm.nih.gov/pubmed/21813761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107594108 |
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