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Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma
The expression of ganglioside GD3, which plays crucial roles in normal brain development, decreases in adults but is upregulated in neoplastic cells, where it regulates tumor invasion and survival. Normally a buildup of GD3 induces apoptosis, but this does not occur in gliomas due to formation of 9-...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3158019/ https://ncbi.nlm.nih.gov/pubmed/21807667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor108 |
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