Urokinase Plasminogen Activator Inhibits HIV Virion Release from Macrophage-Differentiated Chronically Infected Cells via Activation of RhoA and PKCε

BACKGROUND: HIV replication in mononuclear phagocytes is a multi-step process regulated by viral and cellular proteins with the peculiar feature of virion budding and accumulation in intra-cytoplasmic vesicles. Interaction of urokinase-type plasminogen activator (uPA) with its cell surface receptor...

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Bibliographic Details
Main Authors: Graziano, Francesca, Elia, Chiara, Laudanna, Carlo, Poli, Guido, Alfano, Massimo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157461/
https://ncbi.nlm.nih.gov/pubmed/21858203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023674
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