Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jiang, Zhihua, Kamath, Ravindra, Jin, Shunquian, Balasubramani, Manimalha, Pandita, Tej K, Rajasekaran, Baskaran
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2011
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157453/
https://ncbi.nlm.nih.gov/pubmed/21781306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-88
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