Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...

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Autores principales: Jiang, Zhihua, Kamath, Ravindra, Jin, Shunquian, Balasubramani, Manimalha, Pandita, Tej K, Rajasekaran, Baskaran
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157453/
https://ncbi.nlm.nih.gov/pubmed/21781306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-88
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