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Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl
BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3157453/ https://ncbi.nlm.nih.gov/pubmed/21781306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-88 |
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