Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

BACKGROUND: The proto-oncogene, c-Abl encodes a ubiquitously expressed tyrosine kinase that critically governs the cell death response induced by genotoxic agents such as ionizing radiation and cisplatin. The catalytic function of Abl, which is essential for executing DNA damage response (DDR), is n...

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Bibliografiske detaljer
Main Authors: Jiang, Zhihua, Kamath, Ravindra, Jin, Shunquian, Balasubramani, Manimalha, Pandita, Tej K, Rajasekaran, Baskaran
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157453/
https://ncbi.nlm.nih.gov/pubmed/21781306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-88
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