Inclusion Body Myositis: Laser Microdissection Reveals Differential Up-Regulation of IFN-γ Signaling Cascade in Attacked versus Nonattacked Myofibers

Sporadic inclusion body myositis (IBM) is a muscle disease with two separate pathogenic components, degeneration and inflammation. Typically, nonnecrotic myofibers are focally surrounded and invaded by CD8(+) T cells and macrophages. Both attacked and nonattacked myofibers express high levels of hum...

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Bibliographic Details
Main Authors: Ivanidze, Jana, Hoffmann, Reinhard, Lochmüller, Hanns, Engel, Andrew G., Hohlfeld, Reinhard, Dornmair, Klaus
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2011
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157228/
https://ncbi.nlm.nih.gov/pubmed/21855683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.055
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