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Quake: quality-aware detection and correction of sequencing errors
We introduce Quake, a program to detect and correct errors in DNA sequencing reads. Using a maximum likelihood approach incorporating quality values and nucleotide specific miscall rates, Quake achieves the highest accuracy on realistically simulated reads. We further demonstrate substantial improve...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156955/ https://ncbi.nlm.nih.gov/pubmed/21114842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2010-11-11-r116 |
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