Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that affects spinal cord and cortical motor neurons. An increasing amount of evidence suggests that mitochondrial dysfunction contributes to motor neuron death in ALS. Peroxisome proliferator-activated recepto...

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Detalhes bibliográficos
Main Authors: Zhao, Wei, Varghese, Merina, Yemul, Shrishailam, Pan, Yong, Cheng, Alice, Marano, Paul, Hassan, Sadiq, Vempati, Prashant, Chen, Fei, Qian, Xianjuan, Pasinetti, Giulio M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156746/
https://ncbi.nlm.nih.gov/pubmed/21771318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-51
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