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A Concise Synthesis of the Molecular Framework of Pleuromutilin
Two syntheses of the tricyclic carbon skeleton of pleuromutilin are reported. Diastereoselective 1,4-conjugate additions were used to elaborate bicyclic precursors at an early stage of each route, while ring-forming olefin metatheses were executed to complete the pleuromutilin carbon framework. The...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156455/ https://ncbi.nlm.nih.gov/pubmed/21079876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc04077k |
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