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Essential role of Stat3 in PI3K-induced oncogenic transformation
Cells transformed by the p110α-H1047R mutant of PI3K show increased tyrosine phosphorylation of Stat3. This activation of Stat3 is important for the transformation process, because a dominant-negative mutant of Stat3 interferes with PI3K-induced oncogenesis. GDC-0941, a specific inhibitor of PI3K re...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156164/ https://ncbi.nlm.nih.gov/pubmed/21788516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110486108 |
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