GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis

Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy. Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis. In this pathway, Arf6 is activated by EGFR via GEP100. Arf6 is highly exp...

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Detalhes bibliográficos
Main Authors: Hashimoto, Ari, Hashimoto, Shigeru, Ando, Ryo, Noda, Kosuke, Ogawa, Eiji, Kotani, Hirokazu, Hirose, Mayumi, Menju, Toshi, Morishige, Masaki, Manabe, Toshiaki, Toda, Yoshinobu, Ishida, Susumu, Sabe, Hisataka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156124/
https://ncbi.nlm.nih.gov/pubmed/21858086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023359
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