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EGFR Mutation Is a Better Predictor of Response to Tyrosine Kinase Inhibitors in Non–Small Cell Lung Carcinoma Than FISH, CISH, and Immunohistochemistry

About 10% of patients with non–small cell lung carcinoma (NSCLC) respond to epidermal growth factor receptor (EGFR)-targeted tyrosine kinase inhibitors (TKIs). More than 75% of “responders” have activating mutations in EGFR. However, mutation analysis is not widely available, and proposed alternativ...

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Bibliografiske detaljer
Main Authors: Sholl, Lynette M., Xiao, Yun, Joshi, Victoria, Yeap, Beow Y., Cioffredi, Leigh-Anne, Jackman, David M., Lee, Charles, Jänne, Pasi A., Lindeman, Neal I.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156055/
https://ncbi.nlm.nih.gov/pubmed/20472851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1309/AJCPST1CTHZS3PSZ
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