Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

The IFN-inducible immunity-related p47 GTPase Irgm1 has been linked to Crohn disease as well as susceptibility to tuberculosis. Previously we demonstrated that HSC quiescence and function are aberrant in mice lacking Irgm1. To investigate the molecular basis for these defects, we conducted microarra...

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Bibliografski detalji
Glavni autori: King, Katherine Y., Baldridge, Megan T., Weksberg, David C., Chambers, Stuart M., Lukov, Georgi L., Wu, Shihua, Boles, Nathan C., Jung, Sung Yun, Qin, Jun, Liu, Dan, Songyang, Zhou, Eissa, N. Tony, Taylor, Gregory A., Goodell, Margaret A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Hematopoiesis and Stem Cells
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3156044/
https://ncbi.nlm.nih.gov/pubmed/21633090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-328682
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