Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells

Resveratrol (trans-3,5,4’-trihydroxystilbene), a polyphenol found in red wine, has multiple beneficial activities that are similar to caloric restriction. In this study, we analyzed the effect of resveratrol on the gonadotropin genes, follicle-stimulating hormone (FSHβ) and luteinizing hormone (LHβ)...

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Hauptverfasser: Lan, Debin, Lu, Min, Sharma, Shweta, Mellon, Pamela L., Olefsky, Jerrold M., Webster, Nicholas J.G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155991/
https://ncbi.nlm.nih.gov/pubmed/21679764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.reprotox.2011.05.006
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