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Further Activation of FLT3 Mutants by FLT3 Ligand

Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domainor point mutations in the kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL) - independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficie...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zheng, Rui, Bailey, Emily, Nguyen, Bao, Yang, Xiaochuan, Piloto, Obdulio, Levis, Mark, Small, Donald
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155740/
https://ncbi.nlm.nih.gov/pubmed/21516120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.110
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