Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase. Serendipitously, we also found that several predicted farnesyl diphosphate synthase inhibi...

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Bibliographic Details
Main Authors: Durrant, Jacob D, Cao, Rong, Gorfe, Alemayehu A, Zhu, Wei, Li, Jikun, Sankovsky, Anna, Oldfield, Eric, McCammon, J Andrew
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2011
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155669/
https://ncbi.nlm.nih.gov/pubmed/21696546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2011.01164.x
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