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Substantial Contribution of the Two Imidazole Rings of the His13–His14 Dyad to Cu(II) Binding in Amyloid-β (1–16) at Physiological pH and Its Significance
The interaction of amyloid-β (Aβ) peptide with Cu(II) appears to play an important role in the etiology of Alzheimer’s disease. At physiological pH, the Cu(II) coordination in Aβ is heterogeneous, and there exist at least two binding modes in which Cu(II) is coordinated by histidine residues. Electr...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155642/ https://ncbi.nlm.nih.gov/pubmed/21491887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp200379m |
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