LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding

Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain. GTPases often regulate kinases within signal transduction cascades, where GTPases act as molecular switches cycling between a GTP bound “...

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Autores principales: Taymans, Jean-Marc, Vancraenenbroeck, Renée, Ollikainen, Petri, Beilina, Alexandra, Lobbestael, Evy, De Maeyer, Marc, Baekelandt, Veerle, Cookson, Mark R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155532/
https://ncbi.nlm.nih.gov/pubmed/21858031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023207
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