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Novel Menthol-Derived Cooling Compounds Activate Primary and Second-Order Trigeminal Sensory Neurons and Modulate Lingual Thermosensitivity

We presently investigated 2 novel menthol derivatives GIV1 and GIV2, which exhibit strong cooling effects. In previous human psychophysical studies, GIV1 delivered in a toothpaste medium elicited a cooling sensation that was longer lasting compared with GIV2 and menthol carboxamide (WS-3). In the cu...

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Detalhes bibliográficos
Main Authors: Klein, Amanda H., Iodi Carstens, Mirela, McCluskey, T. Scott, Blancher, Guillaume, Simons, Christopher T., Slack, Jay P., Furrer, Stefan, Carstens, Earl
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155393/
https://ncbi.nlm.nih.gov/pubmed/21511802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/chemse/bjr029
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