Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects

Topoisomerase I inhibitors down-regulate HIF-1α leading to tumor growth inhibition, but only while maintaining sustained levels of drug exposure. EZN-2208, a multi-arm 40 kDa pegylated, releasable SN38-drug conjugate, provides higher, longer lasting exposure of tumors to SN38 in contrast to SN38 tha...

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Main Authors: Sapra, Puja, Kraft, Patricia, Pastorino, Fabio, Ribatti, Domenico, Dumble, Melissa, Mehlig, Mary, Wang, Maoliang, Ponzoni, Mirco, Greenberger, Lee M., Horak, Ivan D.
Formato: Artigo
Idioma:Inglês
Publicado: Springer Netherlands 2011
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155047/
https://ncbi.nlm.nih.gov/pubmed/21452059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-011-9209-1
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