Computational design of a β–peptide that targets transmembrane helices

The design of β-peptide foldamers targeting the transmembrane (TM) domains of complex natural membrane proteins has been a formidable challenge. A series of β-peptides was designed to stably insert in TM orientations in phospholipid bilayers. Their secondary structures and orientation in the phospho...

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Bibliografiske detaljer
Main Authors: Shandler, Scott J., Korendovych, Ivan V., Moore, David T., Smith-Dupont, Kathryn B., Streu, Craig N., Litvinov, Rustem I., Billings, Paul C., Gai, Feng, Bennett, Joel S., DeGrado, William F.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155016/
https://ncbi.nlm.nih.gov/pubmed/21780757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204215f
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