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Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation

To examine the role of cyclooxygenase (COX) isozymes in prostaglandin formation and oxidant stress in inflammation, we administered to volunteer subjects placebo or bolus injections of lipopolysaccharide (LPS), which caused a dose-dependent increase in temperature, heart rate, and plasma cortisol. L...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: McAdam, B.F., Mardini, I.A., Habib, A., Burke, A., Lawson, J.A., Kapoor, S., FitzGerald, G.A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2000
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Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC315469/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811855/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI9523
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