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Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation

To examine the role of cyclooxygenase (COX) isozymes in prostaglandin formation and oxidant stress in inflammation, we administered to volunteer subjects placebo or bolus injections of lipopolysaccharide (LPS), which caused a dose-dependent increase in temperature, heart rate, and plasma cortisol. L...

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Main Authors: McAdam, B.F., Mardini, I.A., Habib, A., Burke, A., Lawson, J.A., Kapoor, S., FitzGerald, G.A.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC315469/
https://ncbi.nlm.nih.gov/pubmed/10811855
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