Systemic Par-4 inhibits non-autochthonous tumor growth

The tumor suppressor protein Par-4 (prostate apoptosis response-4) is spontaneously secreted by normal and cancer cells. Extracellular Par-4 induces caspase-dependent apoptosis in cancer cell cultures by binding, via its effector SAC domain, to cell surface GRP78 receptor. However, the functional si...

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Bibliographic Details
Main Authors: Zhao, Yanming, Burikhanov, Ravshan, Brandon, Jason, Qiu, Shirley, Shelton, Brent J, Spear, Brett, Bondada, Subbarao, Bryson, Scott, Rangnekar, Vivek M
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154287/
https://ncbi.nlm.nih.gov/pubmed/21613819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.12.2.15734
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