A Novel α5GABA(A)R-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia

We have shown previously that aberrant hippocampal (HPC) output underlies the dopamine (DA) dysfunction observed in the methylazoxymethanol acetate (MAM) developmental model of schizophrenia in the rodent. This alteration of HPC activity was proposed to result from a reduction in parvalbumin (PV)-ex...

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Detalhes bibliográficos
Main Authors: Gill, Kathryn M, Lodge, Daniel J, Cook, James M, Aras, Shamim, Grace, Anthony A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154109/
https://ncbi.nlm.nih.gov/pubmed/21562483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.76
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