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Inhibition of eukaryotic translation elongation by the antitumor natural product Mycalamide B

Mycalamide B (MycB) is a marine sponge-derived natural product with potent antitumor activity. Although it has been shown to inhibit protein synthesis, the molecular mechanism of action by MycB remains incompletely understood. We verified the inhibition of translation elongation by in vitro HCV IRES...

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Detalhes bibliográficos
Main Authors: Dang, Yongjun, Schneider-Poetsch, Tilman, Eyler, Daniel E., Jewett, John C., Bhat, Shridhar, Rawal, Viresh H., Green, Rachel, Liu, Jun O.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153980/
https://ncbi.nlm.nih.gov/pubmed/21693620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2624511
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