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Dynamic mechanisms for pre-miRNA binding and export by Exportin-5

The biogenesis and function of mature microRNAs (miRNAs) is dependent on the nuclear export of miRNA precursors (pre-miRNA) by Exportin-5 (Exp5). To characterize the molecular mechanisms of how pre-miRNA is recognized and transported by Exp5, we have performed 21 molecular dynamic (MD) simulations o...

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Detalhes bibliográficos
Main Authors: Wang, Xia, Xu, Xue, Ma, Zhi, Huo, Yingqiu, Xiao, Zhengtao, Li, Yan, Wang, Yonghua
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153975/
https://ncbi.nlm.nih.gov/pubmed/21712399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2732611
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