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THE WERNER AND BLOOM SYNDROME PROTEINS HELP RESOLVE REPLICATION BLOCKAGE BY CONVERTING (REGRESSED) HOLLIDAY JUNCTIONS TO FUNCTIONAL REPLICATION FORKS
Cells cope with blockage of replication fork progression in a manner so that DNA synthesis can be completed and genomic instability minimized. Models for resolution of blocked replication involve fork regression to form Holliday junction structures. The human RecQ helicases WRN and BLM (deficient in...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3153593/ https://ncbi.nlm.nih.gov/pubmed/21736299 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2001054 |
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