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A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding
Arrestins regulate the signaling and trafficking of G protein-coupled receptors (GPCRs). GPCR complexes both non-visual arrestins channel signaling to G protein-independent pathways, one of which is the activation of extracellular signal regulated kinase 1/2 (ERK1/2). Here we used alanine-scanning m...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3153575/ https://ncbi.nlm.nih.gov/pubmed/21732673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200745k |
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