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Changes in Conformation at the Cytoplasmic Ends of the Fifth and Sixth Transmembrane Helices of a Yeast G Protein-Coupled Receptor in Response to Ligand Binding

The third intracellular loop (IL3) of G protein-coupled receptors (GPCRs) is an important contact domain between GPCRs and their G proteins. Previously, the IL3 of Ste2p, a Saccharomyces cerevisiae GPCR, was suggested to undergo a conformational change upon activation as detected by differential pro...

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Main Authors: Umanah, George K. E., Huang, Li-Yin, Maccarone, Julianna M., Naider, Fred, Becker, Jeffrey M.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153567/
https://ncbi.nlm.nih.gov/pubmed/21728340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200254h
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