A Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric Assembly

Integrase (IN) is an important therapeutic target in the search for anti-Human Immunodeficiency Virus (HIV) inhibitors. This enzyme is composed of three domains and is hard to crystallize in its full form. First structural results on IN were obtained on the catalytic core domain (CCD) of the avian R...

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Dettagli Bibliografici
Autori principali: Ballandras, Allison, Moreau, Karen, Robert, Xavier, Confort, Marie-Pierre, Merceron, Romain, Haser, Richard, Ronfort, Corinne, Gouet, Patrice
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153463/
https://ncbi.nlm.nih.gov/pubmed/21857987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023032
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