A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBP-J/Su(H) in modulating the pathological outcome

Expanded polyglutamine (polyQ) tract in the human TATA-box-binding protein (hTBP) causes the neurodegenerative disease spinocerebellar ataxia 17 (SCA17). To investigate the pathological effects of polyQ expansion, we established a SCA17 model in Drosophila. Similar to SCA17 patients, transgenic flie...

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Bibliografiska uppgifter
Huvudupphovsmän: Ren, Jie, Jegga, Anil G., Zhang, Minlu, Deng, Jingyuan, Liu, Junbo, Gordon, Christopher B., Aronow, Bruce J., Lu, Long J., Zhang, Bo, Ma, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2011
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153307/
https://ncbi.nlm.nih.gov/pubmed/21653638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr251
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