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Hypoxia Induced Energy Stress Regulates mRNA Translation and Cell Growth
Oxygen deprivation, or hypoxia, has profound effects on cell metabolism and growth. Cells can adapt to low O(2) in part through activation of hypoxia-inducible factor (HIF). We report here that hypoxia inhibits mRNA translation by suppressing multiple key regulators including eIF2α, eEF2, and the mT...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3153113/ https://ncbi.nlm.nih.gov/pubmed/16483933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2006.01.010 |
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