Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons

The K-Cl cotransporter KCC2 plays a crucial role in the functional development of GABA(A)-mediated responses rendering GABA hyperpolarizing in adult neurons. We have previously shown that BDNF upregulates KCC2 in immature neurons through the transcription factor Egr4. The effect of BDNF on Egr4 and...

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Autors principals: Ludwig, Anastasia, Uvarov, Pavel, Pellegrino, Christophe, Thomas-Crusells, Judith, Schuchmann, Sebastian, Saarma, Mart, Airaksinen, Matti S., Rivera, Claudio
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151499/
https://ncbi.nlm.nih.gov/pubmed/21837281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/641248
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