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Actinomycin Analogues Containing Pipecolic Acid: Relationship of Structure to Biological Activity

Streptomyces antibioticus synthesizes a mixture of actinomycins which differ at the “imino acid” site of the peptide chains. In the presence of exogenous pipecolic acid, several new actinomycins were synthesized and 70% of the proline in the antibiotic mixture was replaced by the analogue. Three new...

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Detalhes bibliográficos
Main Authors: Formica, Joseph V., Shatkin, Aaron J., Katz, Edward
Formato: Artigo
Idioma:Inglês
Publicado em: 1968
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC315146/
https://ncbi.nlm.nih.gov/pubmed/4174667
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