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Selective PGE(2) suppression impairs colon carcinogenesis and modifies local mucosal immunity

Prostaglandin E(2) (PGE(2)) is a bioactive lipid that mediates a wide range of physiological effects and plays a central role in inflammation and cancer. PGE(2) is generated from arachidonic acid by the sequential actions of the cyclooxygenases (COXs) and terminal synthases (PGES). Increased levels...

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Main Authors: Nakanishi, Masako, Menoret, Antoine, Tanaka, Takuji, Miyamoto, Shingo, Montrose, David C., Vella, Anthony T., Rosenberg, Daniel W.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151318/
https://ncbi.nlm.nih.gov/pubmed/21576350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0188
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