Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients

Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic compartments and loaded to major histocompatibility complex (MHC) class II molecules...

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Autores principales: Zou, Fang, Schäfer, Nadja, Palesch, David, Brücken, Ruth, Beck, Alexander, Sienczyk, Marcin, Kalbacher, Hubert, Sun, ZiLin, Boehm, Bernhard O., Burster, Timo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151250/
https://ncbi.nlm.nih.gov/pubmed/21850236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022815
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