Interferon-γ regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro

The serine protease cathepsin (Cat) G dominates the proteolytic processing of the multiple sclerosis (MS)-associated autoantigen myelin basic protein (MBP) in lysosomes from primary human B cells and dendritic cells. This is in contrast to B-lymphoblastoid cell lines, where the asparagine endopeptid...

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Autores principales: Burster, Timo, Beck, Alexander, Poeschel, Simone, Øren, Anita, Baechle, Daniel, Reich, Michael, Roetzschke, Olaf, Falk, Kirsten, Boehm, Bernhard O, Youssef, Sawsan, Kalbacher, Hubert, Overkleeft, Herman, Tolosa, Eva, Driessen, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2007
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265925/
https://ncbi.nlm.nih.gov/pubmed/17302735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02540.x
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