Detection of autoreactive CD4 T cells using major histocompatibility complex class II dextramers

BACKGROUND: Tetramers are useful tools to enumerate the frequencies of antigen-specific T cells. However, unlike CD8 T cells, CD4 T cells - especially self-reactive cells - are challenging to detect with major histocompatibility complex (MHC) class II tetramers because of low frequencies and low aff...

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Bibliographic Details
Main Authors: Massilamany, Chandirasegaran, Upadhyaya, Bijaya, Gangaplara, Arunakumar, Kuszynski, Charles, Reddy, Jay
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151213/
https://ncbi.nlm.nih.gov/pubmed/21767394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-12-40
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