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A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis
Conformational dynamics play a key role in enzyme catalysis. While protein motions have clear implications for ligand flux, a role for dynamics in the chemical step of enzyme catalysis has not been clearly established. We generated a mutant of E. coli dihydrofolate reductase (DHFR) that abrogates mi...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3151171/ https://ncbi.nlm.nih.gov/pubmed/21474759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198542 |
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