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Effect of a Phosphodiesterase 5 Inhibitor on Pulmonary and Cerebral Arteries of Newborn Piglets with Chronic Hypoxia-Induced Pulmonary Hypertension

BACKGROUND: The use of phosphodiesterase 5 (PDE5) inhibitors to treat newborns with pulmonary hypertension is increasing. The effect of PDE5 inhibitors on the neonatal cerebral circulation remains unknown. The neonatal piglet model of chronic hypoxia-induced pulmonary hypertension allows the study o...

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Autors principals: Fike, Candice D., Kaplowitz, Mark, Zhang, Yongmei, Dantuma, Mark, Madden, Jane A.
Format: Artigo
Idioma:Inglês
Publicat: S. Karger AG 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151003/
https://ncbi.nlm.nih.gov/pubmed/21791937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000326270
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