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Probing the steric space at the floor of the D(1) dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues
To probe the space at the floor of the orthosteric ligand binding site in the dopamine D(1) receptor, four methylated analogs of dihydrexidine (DHX) were synthesized with substitutions at the 7 and 8 positions. The 8α-axial, 8β-equatorial and 7α-equatorial were synthesized by photochemical cyclizati...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150624/ https://ncbi.nlm.nih.gov/pubmed/21714510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200334c |
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