Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2

Human vaccinia-related kinases (VRK1 and VRK2) are atypical active Ser-Thr kinases implicated in control of cell cycle entry, apoptosis and autophagy, and affect signalling by mitogen activated protein kinases (MAPK). The specific structural differences in VRK catalytic sites make them suitable cand...

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Hlavní autoři: Vázquez-Cedeira, Marta, Barcia-Sanjurjo, Iria, Sanz-García, Marta, Barcia, Ramiro, Lazo, Pedro A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150407/
https://ncbi.nlm.nih.gov/pubmed/21829721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023235
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