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HIF-2α regulates GM-CSF-derived sVEGFR-1 production from macrophages and inhibits tumor growth and angiogenesis
Macrophage secretion of VEGF in response to the hypoxic tumor microenvironment contributes to tumor growth, angiogenesis, and metastasis. We have recently demonstrated that macrophages stimulated with GM-CSF at low O(2) secrete high levels of a soluble form of the VEGF receptor (sVEGFR-1), which neu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3150377/ https://ncbi.nlm.nih.gov/pubmed/21765015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1100841 |
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